Objective To compare the clinical effect of laparoscopic pyeloplasty in children through transperitoneal approach and retroperitoneal approach.Methods From January 2018 to December 2022,123 children aged 14 years and younger who underwent laparoscopic pyeloplasty were collected,including 58 with a transperitoneal approach and 65 with a retroperitoneal approach.The intraoperative and postoperative indices as well as postoperative complications were compared between the two groups.Results The age of the transperitoneal access group was younger than that of the retroperitoneal access group(P<0.05).The time to recovery of gastrointestinal func-tion,time to drainage tube retention and postoperative hospital stay were shorter in the retroperito-neal access group than in the transperitoneal access group(P<0.05),and the postoperative compli-cations were less in the retroperitoneal access group than in the transperitoneal access group(P<0.05).The differences in operative time,intraoperative blood loss or D-J tube removal time between the two groups were not statistically significant(P>0.05).Conclusions A retroperitoneal ap-proach can be chosen for older children,and a transabdominal approach is recommended for low ure-teropelvic junction obstruction and younger children,especially infants.Both approaches have their own advantages,so the surgical approach should be selected according to the developmental,age and anatomical characteristics of the child.Then,the difficulty of surgery and complications can be re-duced,and surgical refinement and success rate can be improved.