Objective To investigate the relationship between serum neutrophil-to-lymphocyte ratio(NLR)and overactive bladder(OAB),as well as to explore whether NLR can be used as a bio-marker to distinguish OAB from healthy individuals.We postulate that elevated NLR levels are intri-cately associated with the classification and severity of OAB.Methods The medical records of 56 adult women diagnosed with OAB at Peking University People's Hospital were analyzed as a cross-sectional study.In addition,data were obtained from a randomly selected cohort of 167 healthy women,and NLR was determined by calculating the ratio of neutrophils to lymphocytes.Additional-ly,symptom assessment questionnaires were collected from OAB patients.Results Baseline anal-ysis showed the NLR was significantly higher in OAB patients than in healthy individuals[(2.46±1.24)vs(1.78±0.65),P＜0.001].Within the OAB group,OAB-wet bladder demonstrated nota-bly divergent NLR levels in comparison to OAB-dry,but without statistically significance(P=0.092).In addition,we observed a significant positive correlation between NLR and Overactive score system(OABSS)scores(P=0.019).The receiver operating characteristic(ROC)analysis yielded an area under the curve(AUC)of 0.733 for NLR in distinguishing OAB from the normal group,and an AUC of 0.701 in distinguishing OAB-wet and OAB-dry.Conclusions This study shows that serum NLR can be used as a non-invasive diagnostic marker in the diagnosis of OAB pa-tients and symptom assessment.
关键词
诊断标志物/膀胱过度活动症/中性粒细胞与淋巴细胞比值
Key words
Diagnostic markers/Overactive bladder/Neutrophil-to-lymphocyte ratio
维普
万方数据