Objective To verify the clinical value of previous established cM0(i+)staging cri-teria in localized renal cell carcinoma(LRCC).Methods The present study enrolled patients with LRCC who had received surgeries at the Department of Urology,the Second Affiliated Hospital of Xi'an Jiaotong University from May 2015 to November 2021 retrospectively,and defined them as the validation group.Kaplan-Meier analysis and Log-rank test were performed using postoperative circulating tumor cells(CTCs)data.Univariate and multivariate Cox regression analysis were per-formed to validate the correlation between CTCs and progression-free survival(PFS).Time-depend-ent receiver operator characteristic(ROC)curve was utilized to evaluate the discrimination of the cM0(i+)staging criteria.Prognosis of the patients enrolled was predicted using a nomogram.SPSS 26.0 software and R Studio software were used to conduct the above analyses,and p value less than 0.05 was considered to be statistically significant.Results In patients with LRCC,Kaplan-Meier analysis showed that patients with cM0(i+)stage had significantly shorter PFS than those in the control group.The results of multivariate Cox regression analysis showed that cM0(i+)stage was an independent risk factor in postoperative progression of LRCC patients,and the predictive discrimi-nation area under the curve(AUC)was 0.832(0.737-0.926).The predictive discrimination of the nomogram established based on the cM0(i+)stage and clinicopathological features was 0.914(0.893-0.935).Conclusions The cM0(i+)stage is an independent risk factor in postoperative progression of patients with LRCC,and can accurately determine LRCC patients with short PFS.The nomogram established based on cM0(i+)stage and clinicopathological features of patients with LRCC has a favorable predictive effect on the progno-sis of these patients.
维普
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