Major molecular targets and current registration and resistance status of commercial systemic fungicides
Most systemic fungicides act on a single target site,demonstrating high or super-high activity against plant pathogens and playing an indispensable role in the effective control of plant diseases.However,improper usage of fungicides can result in the development of resistance.Notably,out of the nearly 220 fungicides available worldwide,37 are C14 demethylase inhibitors,24 target mitochondrial respiratory complex Ⅱ,26 target mitochondrial respiratory complex Ⅲ,9 target β-tubulin,7 target RNA polymerase I,7 target cellulose synthase,3 target adenosine deaminase,2 target oxysterol-binding proteins related proteins,2 target vacuolar H+-ATPase,1 target myosin-5,and 1 target chitin synthase.This article provided a brief overview of 12 target proteins,the registration status,and resistance occurrences of the above 11 classes of fungicides in China.The aim of this review was to provide guidance for the appropriate use of these fungicides and strategies for managing fungicide resistance.
fungicidemolecular targetmode of actionregistration statusresistance status