摘要
为开发结构新颖、活性高且对环境友好的绿色农药,以呋喃葡萄糖为基本骨架,引入活性基团噻唑,设计并合成了 2 9个葡萄糖噻唑类化合物.利用核磁共振氢谱、碳谱及质谱等对目标化合物结构进行确认,并测试了 目标化合物对黄瓜灰霉病菌、甜瓜枯萎病菌、番茄枯萎病菌、胶孢炭疽病菌、草莓炭疽病菌、串珠镰刀病菌等6种病原菌的杀菌活性.结果表明:在质量浓度为50 μg/mL时,目标化合物对供试菌种均表现出一定的抑制活性.部分目标化合物对番茄枯萎病菌、胶孢炭疽病菌、草莓炭疽病菌的抑制率在50％以上;对黄瓜灰霉病菌的抑菌活性较好,尤其是化合物F-4,表现出90.3％的抑制率,具有进一步研究的价值.
Abstract
To develop green pesticides with novel structures,thiazole structure was introduced into furan glucose,and twenty nine glucose thiazole compounds were designed and synthesized.Their structures were characterized by 1H NMR,13C NMR,HRMS.The fungicidal activity tests showed that at the concentration of 50 μg/mL,the target compounds exhibited certain fungicidal activities against Botrytis cinerea,Fusarium oxysporum,Colletotrichum gloeosporioides,Colletotrichum fragariae,Fusarium moniliforme.The inhibition rates of some compounds were over 50％against Fusarium oxysporum,Colletotrichum gloeosporioides,and Colletotrichum fragariae.All the compounds had certain antifungal activities against Botrytis cinerea,especially compound F-4,with the inhibitory rate of 90.3％.
基金项目
北京市自然科学基金(2232004)
北京农学院学位与研究教育改革与发展项目(2023YJS026)
维普
万方数据