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RNA杀虫剂研究进展

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RNA生物农药是通过靶标生物体内天然存在的RNA干扰(RNA interference,RNAi)通路,干扰或抑制靶标生物特定基因转录或表达的多核苷酸制剂,是一种具有巨大开发及应用潜力的新型绿色的生物农药.首先介绍了dsRNA/siRNA、miRNA和piRNA这3种RNAi通路的作用机制,然后综述了 dsRNA和miRNA生物农药在害虫防治领域的研究进展及其商品化进展,并总结了 dsRNA和miRNA生物农药的异同点,最后分析了 RNA生物农药在未来应用中可能遇到的问题,并提出了合理的建议.以期为RNA生物农药的研发与应用提供参考,为害虫的综合防控提供新的理念.
Research advances on RNA insecticides
RNA biopesticides are polynucleotide preparations that inhibit the transcription or expression of specific genes in target organisms through naturally occurring RNA interference pathways,which is a new green biopesticide with enormous development and application potential.The mechanism of the three RNAi pathways,dsRNA/siRNA,miRNA,and piRNA were introduced in this paper.Then,the research progress and commercialization progress of dsRNA,miRNA biopesticides in the field of pest control,and the similarities and differences between dsRNA and miRNA biopesticides were summarized.Finally,the possible problems that might be encountered in the future application of RNA biopesticides were analyzed and reasonable suggestions were put forward.This review provided references for the research and application of RNA biopesticides,and offered new ideas for comprehensive pest control.

RNA biopesticideRNA interferencedouble stranded RNAmicroRNApest control

李琳红、王海宝、梁沛

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中国农业大学植物保护学院昆虫学系,北京 100193

中国农业大学三亚研究院,海南三亚 572025

RNA生物农药 RNA干扰 双链RNA 微小RNA 害虫防治

2024

现代农药
江苏省农药协会 江苏省农药研究所股份有限公司 江苏省农药科技信息站

现代农药

CSTPCD
影响因子:0.471
ISSN:1671-5284
年,卷(期):2024.23(4)