Synthesis and biological activity of cinnamate derivatives containing triazole group
Nineteen cinnamate derivatives were designed and synthesized by splicing with the biologically active factor containing triazole group.The structures of the new compounds were characterized by'H NMR,13C NMR and HRMS.The results of bioactivity tests showed that the EC50 of compound Ⅵc against Fusarium moniliforme was 9.22 mg/L,which was higher than the EC50 of diniconazole(6.14 mg/L).At the concentration of 50 mg/L,the inhibition rate of compound Ⅵc against Ralstonia solanacearum was 22.24％,which was lower than that of thiodiazole copper 20％SC(27.41％).Compound Ⅵ c had the activity of both antifungal and antibacterial,which could be used as a lead compound for the further study.
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