现代农药2024,Vol.23Issue(4) :29-37.DOI:10.3969/j.issn.1671-5284.2024.04.005

含三唑基团的肉桂酸酯衍生物的合成及生物活性

Synthesis and biological activity of cinnamate derivatives containing triazole group

游江 王济海 刘贺 周强
现代农药2024,Vol.23Issue(4) :29-37.DOI:10.3969/j.issn.1671-5284.2024.04.005

含三唑基团的肉桂酸酯衍生物的合成及生物活性

Synthesis and biological activity of cinnamate derivatives containing triazole group

游江 1王济海 2刘贺 1周强1
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作者信息

  • 1. 顺毅宜昌化工有限公司,湖北宜昌 443000
  • 2. 湖北省荆州市北门中学,湖北荆州 434000
  • 折叠

摘要

将肉桂酸与含三唑基团的活性亚结构拼接设计合成了 19个含三唑基团的肉桂酸酯衍生物Ⅵa~Ⅵs.化合物结构经过1H NMR、13C NMR和HRMS确证.生物活性测试结果显示:化合物Ⅵc对水稻恶苗病菌的EC50为9.22 mg/L,略高于对照药剂烯唑醇(6.14 mg/L).在质量浓度为50 mg/L时,化合物Ⅵc对生姜青枯病菌的抑制率为22.24%,稍低于对照药剂20%噻菌铜悬浮剂(27.41%).化合物Ⅵc具有一定的抑制真菌和细菌的活性,可作为先导化合物进一步研究.

Abstract

Nineteen cinnamate derivatives were designed and synthesized by splicing with the biologically active factor containing triazole group.The structures of the new compounds were characterized by'H NMR,13C NMR and HRMS.The results of bioactivity tests showed that the EC50 of compound Ⅵc against Fusarium moniliforme was 9.22 mg/L,which was higher than the EC50 of diniconazole(6.14 mg/L).At the concentration of 50 mg/L,the inhibition rate of compound Ⅵc against Ralstonia solanacearum was 22.24%,which was lower than that of thiodiazole copper 20%SC(27.41%).Compound Ⅵ c had the activity of both antifungal and antibacterial,which could be used as a lead compound for the further study.

关键词

肉桂酸/三唑/新化合物/合成/生物活性

Key words

cinnamic acid/triazole/new compound/synthesis/bioactivity

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出版年

2024
现代农药
江苏省农药协会 江苏省农药研究所股份有限公司 江苏省农药科技信息站

现代农药

CSTPCD
影响因子:0.471
ISSN:1671-5284
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