现代农药2024,Vol.23Issue(4) :38-40,54.DOI:10.3969/j.issn.1671-5284.2024.04.006

联苯吡菌胺中间体2-(3,4-二氯苯基)-4-氟苯胺的合成研究

Study on synthesis of bixafen intermediate 2-(3,4-dichlorophenyl)-4-fluoroaniline

曹燕蕾
现代农药2024,Vol.23Issue(4) :38-40,54.DOI:10.3969/j.issn.1671-5284.2024.04.006

联苯吡菌胺中间体2-(3,4-二氯苯基)-4-氟苯胺的合成研究

Study on synthesis of bixafen intermediate 2-(3,4-dichlorophenyl)-4-fluoroaniline

曹燕蕾1
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作者信息

  • 1. 江苏省农药研究所股份有限公司,南京 210046
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摘要

研究了联苯吡菌胺中间体2-(3,4-二氯苯基)-4-氟苯胺的合成路线.以3,4-二氯苯胺为起始原料,经重氮化、亚硫酸钠还原得到3,4-二氯苯肼,再与4-氟苯胺在碱性条件下通入空气偶联得到目标产物2-(3,4-二氯苯基)-4-氟苯胺.以3,4-二氯苯胺计,目标产物收率80%以上,质量分数90%以上.与其他工艺路线相比,该路线具有原料价廉、易于保存,操作简单,收率较高,易纯化等优点.

Abstract

In this paper,the synthetic routes of bixafen intermediate 2-(3,4-dichlorophenyl)-4-fluoroaniline were studied.3,4-Dichlorophenylhydrazine was prepared from 3,4-dichloroaniline by diazotization and reduction reaction,and then it was coupled with 4-fluoroaniline in air under alkaline conditions to obtain the target product.The yield of the target product was above 80%,and the content was more than 90%,calculated by 3,4-dichloroaniline.Compared with other process routes,this route had the advantages of cheap raw materials,easy preservation,simple operation,high yield,and easy purification.

关键词

2-(3,4-二氯苯基)-4-氟苯胺/联苯吡菌胺/3,4-二氯苯胺/4-氟苯胺/重氮化/合成

Key words

2-(3,4-dichlorophenyl)-4-fluoroaniline/bixafen/3,4-dichloroaniline/4-fluoroaniline/diazotization/synthesis

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出版年

2024
现代农药
江苏省农药协会 江苏省农药研究所股份有限公司 江苏省农药科技信息站

现代农药

CSTPCD
影响因子:0.471
ISSN:1671-5284
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