Preparation and characterization of physcion microcapsule sustained release agent
To prepare physcion microcapsule sustained release agent,the physcion was made into microemulsion to increase its solubility,and in-situ polymerization was used to encapsulate physcion microemulsion with melamine-formaldehyde resin as capsule wall.The solubility of physcion in microemulsion was about 5 g/L,which was significantly higher than that in other solvents.The favorable loading capacities and encapsulation efficiencies were achieved with physcion microemulsion as core(containing 30％water),the ratio of core and wall was 3∶1.The accumulative release amounts of physcion were 72.0％and 51.9％in water(14 d)and in soil(35 d),respectively.The microcapsule sustained release agent had the advantages of uniform distribution,high drug loading,slow and long-lasting drug release,and could reduce the frequency of application,and had important practical application value.
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