大黄素甲醚微囊缓释剂的制备及表征
Preparation and characterization of physcion microcapsule sustained release agent
王亚晶 1史莹莹 1伏莉 1吕世群 1丁子微 1刘杰 1黄险峰1
作者信息
- 1. 常州大学药学院,江苏常州 213164
- 折叠
摘要
制备一种大黄素甲醚微囊缓释剂,将大黄素甲醚制成微乳液,提高其溶解度,进一步采用原位聚合法,以密胺树脂作为囊壁,将大黄素甲醚微乳液微囊化.微乳液中大黄素甲醚的溶解度约为5 g/L,明显高于在其他溶剂中溶解度.当囊芯为微乳液(含水量30％),密胺树脂为囊壁,芯壁比(质量比)为3∶1时,所制大黄素甲醚微囊缓释剂的载药量和包封率最高,在水中14d累积释放率为72.0％,土壤中35 d累积释放率为51.9％.该微囊缓释剂分布均匀、载药量高、释药缓慢持久,用于病害防控可减少给药次数,具有重要的实际应用价值.
Abstract
To prepare physcion microcapsule sustained release agent,the physcion was made into microemulsion to increase its solubility,and in-situ polymerization was used to encapsulate physcion microemulsion with melamine-formaldehyde resin as capsule wall.The solubility of physcion in microemulsion was about 5 g/L,which was significantly higher than that in other solvents.The favorable loading capacities and encapsulation efficiencies were achieved with physcion microemulsion as core(containing 30％water),the ratio of core and wall was 3∶1.The accumulative release amounts of physcion were 72.0％and 51.9％in water(14 d)and in soil(35 d),respectively.The microcapsule sustained release agent had the advantages of uniform distribution,high drug loading,slow and long-lasting drug release,and could reduce the frequency of application,and had important practical application value.
关键词
大黄素甲醚/微乳液/微囊缓释剂/制备Key words
physcion/microemulsion/microcapsule sustained release agent/prepare引用本文复制引用
基金项目
江苏省研究生科研与实践创新计划(SJCX221314)
出版年
2024
NETL
NSTL
万方数据