Determination of fosthiazate and imidacloprid in variety formulations based on HPLC-UV-QDa
A high performance liquid chromatography-ultraviolet detector-mass spectrometry(HPLC-UV-QDa)method was developed for the determination of fosthiazate and imidacloprid in 5 different formulations.The samples were analyzed by gradient elution separation,using acetonitrile-water(0.05％formic acid)as the mobile phase on C18 column.The results showed that the linear relations were good at the concentration of 0.05-50 mg/L,R2 of fosthiazate and imidacloprid were 0.999 2-0.999 9 and 0.999 1-0.999 6,respectively.Under the level of 0.5,50,500 mg/kg,the recoveries of fosthiazate and imidacloprid were 90.2％-103.9％and 94.7％-104.1％,and the relative standard deviations were 1.04％-6.69％and 1.27％-5.88％,respectively.The matrix effects of fosthiazate and imidacloprid were non-obvious in 5 typical substrates,and LOD were 0.005 and 0.01 mg/L,LOQ were 0.02 and 0.04 mg/kg.The method was suitable for the analysis of fosthiazate and imidacloprid in different formulations.
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