Research progress on metabolic transformation of pesticides in animals
The wide application of pesticides leads to direct or indirect exposure of humans and other animals to pesticides.After pesticides enter the animal body through the mouth,skin or respiratory system,their mothers and toxic metabolites can have a negative impact on animal endocrine and other aspects.The metabolic transformation process of pesticides in animals is mainly divided into two stages:primary metabolism(phase Ⅰ)and secondary metabolism(phase Ⅱ).Phase Ⅰ metabolism is mainly through the process of cytochrome P450 enzyme system,including oxidation,hydrolysis and reduction.Phase Ⅱ metabolism is a conjugation reaction between phase Ⅰ metabolites(or original pesticide)and endogenous substances with the participation of glutathione transferase.It is important to understand the metabolic transformation behavior of pesticides in animals for accurate risk assessment and safe use of pesticides.The metabolic transformation process,influencing factors and research methods of metabolic transformation of pesticides in animals,as well as the potential risks of pesticide metabolism in animals was reviewed in this paper,in order to provide references for rational application of pesticides,accurate assessment and control of pesticide health risks to non-target animals.
万方数据
维普
