Preparation and Properties of Nanofiber Membranes Loaded with Luteolin
Two pH sensitive materials(Eudragit S100 and Eudragit RS100)were used to prepare shell/core structure nanofiber membranes loaded with luteolin by coaxial electrospinning technology.The surface morphology,chemical structure and drug release performance of shell/core structure nanofiber membranes loaded with luteolin were studied by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and so on.The results show that the surface of shell/core structure nanofiber membranes loaded with luteolin is generally smooth.The average diameter of the nanofibers increases with the increase of luteolin content.The nanofiber membrane has good colon targeting and biocompatibility.
coaxial electrospinning technologyshell/core structureluteolincolonic targetingslow release and controlled release
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