Two pH sensitive materials(Eudragit S100 and Eudragit RS100)were used to prepare shell/core structure nanofiber membranes loaded with luteolin by coaxial electrospinning technology.The surface morphology,chemical structure and drug release performance of shell/core structure nanofiber membranes loaded with luteolin were studied by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and so on.The results show that the surface of shell/core structure nanofiber membranes loaded with luteolin is generally smooth.The average diameter of the nanofibers increases with the increase of luteolin content.The nanofiber membrane has good colon targeting and biocompatibility.
关键词
同轴静电纺丝技术/壳/核结构/木犀草素/结肠靶向/缓释控释
Key words
coaxial electrospinning technology/shell/core structure/luteolin/colonic targeting/slow release and controlled release
维普
万方数据