不同严重程度OSAHS对患者认知功能及情绪状况的影响
Effects of obstructive sleep apnea hypopnea syndrome on cognitive function and the emotion state of OSAHS patients
郭霞 1赵雅宁 2喻昌利 1李琳 1王红阳1
作者信息
- 1. 河北联合大学附属医院呼吸科,河北唐山063000
- 2. 河北联合大学护理学院
- 折叠
摘要
目的 探讨不同严重程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对患者认知功能及情绪状况的影响.方法 选择在河北联合大学附属医院就诊的97例阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者,依据睡眠呼吸暂停低通气指数AH Ⅰ分为轻、中、重3组.同时向患者发放简易智能精神状态检查量表(MMSE)、Zung抑郁自评量表(SDS)及焦虑自评量表(SAS).结果 重度OSAHS组MMSE总分(22.45±1.08)明显低于轻(26.41±1.22)、中度(26.34±1.13) OSAHS组,差异有统计学意义(F--121.53,P＜0.05);在记忆力(1.74±0.45)、注意力和计算力(3.18±0.49)、回忆能力( 1.92±0.45)得分明显低于轻(2.86±0.51、4.51±0.53、2.93±0.46)、中度(2.57±0.49、4.31±0.50、2.74±0.47) OSAHS组,差异有统计学意义(F=45.68、62.84、43.08,P＜0.01);重度OSAHS组患者SDS (51.29±5.73)、SAS (52.74±5.45)标准分均明显高于轻(47.77±5.65、47.86±4.51)、中度(48.31±5.67、48.57±4.49)OS-AHS组,差异有统计学意义(F=3.52、9.48,P＜ 0.05).结论 重度OSAHS患者较轻、中度OSAHS患者认知功能明显下降,主要表现在记忆、计算、回忆方面的损害.重度OSAHS患者较轻、中度OSAHS患者存在明显的焦虑抑郁情绪.
Abstract
OBJECTIVE To assess the effect of obstructive sleep apnea hypopnea syndrome on cognitive function and the emotion state of OSAHS patients- METHODS 97 patients with OSAHS were collected from the Affilated Hospital of Hebei Union U-niversity, and they were divided into three groups according to apnea-hypopnea index (AHI), including mild group, moderate group and severe group. They were assessed by Mini Mental State Examination (MMSE), Self-Rating Depression Scale (SDS) and the Self-Rating Anxiety Scale (SAS). RESULTS The total score of MMSE and scores of MMSE in memory, attention and calculation, recollection function decreased significantly in the severe OSAHS group (22.45 ± 1.08, 1.74 ± 0.45, 3.18 ± 0.49 and 1.92 ± 0.45) than those in the mild (26.41 ± 1.22, 2.86 ± 0.51, 4.51 ± 0.53 and 2.93 ± 0.46) and moderate (2634 ± 1.13, 2.57 ± 0.49, 4.31 ± 0.50 and 2.74 ± 0.47) group (F = 121.53, 45.68, 62.84 and 43.08, P< 0.01); The total scores of MMSE in memory, attention and calculation and recollection function had no significant difference between the mild and moderate groups (P> 0.05). ③The scores of SDS and SAS in the severe OSAHS (51.29 ± 5.73 and 52.74 ± 5.45) group significantly higher than those in the mild (47,77 ± 5.65 and 47.86 ± 4.51) and moderate (48.31 ± 5.67 and 48.57 ± 4.49) groups (P< 0.05); There were no significant differences between the mild group and the moderate group (F= 3.52 and 9.48, P< 0.05). CONCLUSION A significant decrease was found in cognitive function among patients with severe OSAHS, especially for memory, attention and calculation as well as recollection function. There was the apparent anxiety-depression emotions in patients with OSAHS.
关键词
阻塞性睡眠呼吸暂停低通气综合征/简易智能精神状态检查量表/认知障碍/抑郁自评量表/焦虑自评量表Key words
Obstructive Sleep Apnea-Hypopnea Syndrome/Mini mental state examination/Cognitive disorders/Self-Rating depression scale/Self-rating anxiety scale引用本文复制引用
基金项目
河北省科技支撑课题(09276103D-11)
出版年
2012
NETL
NSTL
维普
万方数据