Solid phase extraction-gas chromatography-tandem mass spectrometry method for determining 21 types of herbicides in drinking water
Objective To establish a gas chromatography-tandem mass spectrometry(GC-MS/MS)method for detecting 21 types of herbicides in drinking water based on solid phase extraction(SPE)pre-treatment technology.Methods A 500 ml water sample was extracted using a C18 solid phase extraction column,followed by elution with a 5 ml mixture of ethyl acetate and dichloromethane(1∶1).The eluent was collected and concentrated near dryness using vacuum centrifugation,and then reconstituted with 1 ml of ethyl acetate for analysis by gas chromatography-mass spectrometry in multiple reaction monitoring(MRM)mode.Results Within the concentration range of 5.0 μg/L to 200.0 μg/L,the herbicides exhibited good linearity,with correlation coefficients ranging from 0.9 954 to 0.9 998.The limits of detection(LOD)ranged from 0.11 μg/L to 1.21 μg/L,while the limits of quantification(LOQ)ranged from 0.33 μg/L to 3.64 μg/L.Precision(RSD)was found to be between 1.6％and 6.3％,and the recovery rates ranged from 74.3％to 112.7％.Conclusion This method demonstrates a wide linear range,accuracy,and reliability,making it suitable for the detection of multiple herbicides in water.
Solid phase extractionGas chromatography-tandem mass spectrometryDrinking waterHerbicides
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