Study on the health benefits of ozone simulation interventions for diabetes based on a prospective cohort
Objective To quantify the health benefits of interventions targeting ozone exposure on diabetes prevalence under different strategies,providing scientific support for policies aimed at reducing atmospheric ozone levels to mitigate diabetes.Methods Utilizing questionnaire,physical examination data,and atmospheric data from a cohort of 16 607 participants in Chengdu,Southwest China,we employed a Logistic regression model to explore the association between ozone and diabetes risk.We simulated ratio interventions,fixed-value interventions,and threshold interventions for ozone concentration using the parametric G formula method to quantify the reduction in diabetes prevalence under each intervention strategy.Results An increase of 1 mg/m3 in ozone corresponded to an odds ratio(OR)of 1.07(95％CI:1.01-1.13).Reducing ozone concentration by 5％,controlling it at P50(85.20 mg/m3),or lowering it to P75(86.12 mg/m3)or below could respectively reduce diabetes prevalence by 27.38％(23.47％-31.28％),8.35％(4.01％-12.70％),and 10.50％(6.00％-15.01％).Conclusion Various strategies to intervene on ozone concentration can reduce diabetes prevalence,with ratio interventions showing the most significant effectiveness.Future measures should consider local ozone levels and comprehensively account for seasonal variations,regional differences,and pollution sources to implement interventions aimed at percentage reductions in overall ozone concentration,thereby reducing diabetes risk.
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