Association study of aspartate aminotransferase/alanine aminotransferase ratio with diabetes risk in the Chinese population:a retrospective cohort study based on the DRYAD database
Objective To investigate the relationship between the aspartate aminotransferase(AST)to alanine aminotransferase(ALT)ratio and the incidence of diabetes in the Chinese population.Methods Data of Chinese adults from 2010 to 2016 were extracted from the DRYAD database.Cox regression models were employed to explore the association between the AST/ALT ratio and diabetes incidence,while smooth curve fitting was used to identify non-linear relationships.A piecewise linear regression function was applied to determine the optimal risk threshold.Results A total of 86 145 participants were included in the study.After adjusting for covariates,a negative correlation was found between the AST/ALT ratio and diabetes inci-dence(HR=0.44,95％CI:0.38-0.51,P＜0.001).The piecewise linear regression function identified the optimal risk threshold at 1.3.For values to the left of the threshold,HR=0.3,95％CI:0.2-0.3,P＜0.001;for values to the right,HR=0.9,95％CI:0.7-1.2,P=0.561.Conclusion The AST/ALT ratio is a predictor of diabetes occurrence and is negatively correlated with diabetes incidencè.
NETL
NSTL
万方数据
