The application value of 99m Tc-MDP SPECT/CT bone imaging in the differential diagnosis of benign and malignant primary bone tumor and tumor-like disease
Objective To investigate the application value of SPECT/CT bone imaging in the differential diagnosis of benign and malignant primary bone tumor and tumor-like disease.Methods The retrospective analysis was performed on 75 patients,a total of 128 lesions,with primary bone tumor and tumor-like disease who underwent 99m Tc-MDP whole bone scan and SPECT/C T bone imaging in our hospital from May 2014 to May 2023.They were finally diagnosed by surgical pathology or biopsies or follow-up.The diagnostic efficacy of the three tomography of SPECT,CT and SPECT/CT on the same machine were analyzed.Results Among 128 lesions,88 benign and 40 malignant.One case of invasive giant cell tumor of bone and the local malignancy of two cases of enchondroma and one case of osteochondroma were diagnosed early.Using SPECT、CT and SPECT/CT imaging for the differential diagnosis of benign and malignant primary bone tumor and tumor-like disease of 128 lesions,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 70.6%(36/51)vs 87.2%(34/39)vs 97.4%(38/39),94.8%(73/77)vs 93.3%(83/89)vs 97.8%(87/89),90.0%(36/40)vs 85.0%(34/40)vs 98.9%(87/88),82.9%(73/88)vs 94.3%(83/88)vs 95.0%(38/40),85.2%(109/128)vs 91.4%(117/128)vs 97.7%(125/128),respectively.The value of SPECT/CT imaging in diagnosing primary bone tumor and tumor-like disease was higher than SPECT and CT,The former sensitivityand accuracy(P<0.05),the latter positive predictive value(P<0.05),the pairwise comparison were statistically significant.Conclusion SPECT/CT imaging has higher diagnostic accuracy,sensitivity,specificity,positive predictive value and negative predictive value in the differential diagnosis of benign and malignant primary bone tumor and tumor-like disease.Especially,the early diagnosis of invasive primary bone tumors and local malignant transformation of benign bone tumor or bone tumor-like lesions has great advantages.99m Tc-MDP SPECT/CT imaging has important clinical application value.
Primary bone tumorsTumor-like diseaseRadionuclide imagingDiagnosisTomographyEmission-computedSingle-photo
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