Objective To evaluate the biocompatibility of different types of pressure sensitive adhesive for medical devices,which provides theoretical support for scientific supervision of the pressure-sensitive adhesive.Methods Based on a series of GB/T 16886 medical equipment biology evaluation standards,Pressure sensitive adhesive for medical devices were subjected to a series of tests,including MTT cytotoxicity test in vitro,neutral red uptake test,and hemocompatibility test and Partial thromboplastin time.Results The cell survival rates of the YP3 and YP4 were less than 70%at 40μm thicknesses,The neutral red phagocytosis rates of theYP1,YP3 and YP4 were reduced to<50%of the blank.at thicknesses of 20μm and 40μm.The hemolysis rates of theYP1,YP3 and YP4 were more than 5%at thicknesses of 10μm,20μm and 40μm.The partial thromboplastin time of YP3 and YP4 compared with blank control were less than 80%at thicknesses of 20μm and 40μm.Conclusion Under the current test conditions,the acrylic emulsion pressure sensitive adhesive showed a potential biocompatibility with potential cytotoxicity,inhibition of cellular phagocytic functionhemolytic effect and blood coagulation effect,especially for YP3 and YP4 at some thicknesses.
维普
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