首页|孔径形状控制器和收敛模式在宫颈癌容积旋转调强放疗计划中的应用

孔径形状控制器和收敛模式在宫颈癌容积旋转调强放疗计划中的应用

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目的 研究Eclipse计划系统中孔径形状控制器(Aperture Shape Controller,ASC)和收敛模式(Convergence Mode,CM)两优化子算法对宫颈癌容积旋转调强放疗计划质量和复杂度的影响。方法 本文为回顾性分析,选取2021年7月—2023年7月在宜宾市第一人民医院肿瘤科(放疗科)经明确病理诊断为Ⅰ~ⅣA期的宫颈癌患者30例,通过改变ASC设置(off、low、moderate、high)和CM设置(off、on),分别对所选病例VMAT方案进行重新优化。利用计划质量评价参数和复杂度指标对放疗计划进行评价。结果 对于计划靶区(Planning Target Volume,PTV)而言,其中均质性指数(Homogeneity Index,HI)、适形指数(Conformity Index,CI)(除对比组Ⅰ与Ⅴ组外)、D2、D50和D98相比于CM设置为off,CM设置为on时,差异有统计学意义(P<0。05)。当CM设置为off或on时,随着ASC设置依次为off、low、moderate、high,HI、CI、D 2、D 50和D98均呈增大趋势。肠道V45除对比组Ⅰ与Ⅴ组、Ⅰ与Ⅱ组和Ⅴ与Ⅵ组外,其他差异均有统计学意义(P<0。05)。当CM设置为off或on时,随着ASC设置的优先级增加,肠道V45、膀胱V50、左右侧股骨头V20与V30均呈增大趋势。MU、ALT、ABW、LTMCS和AMCS的变化降低了计划的复杂性。与CM设置为off相比,CM设置为on优化总平均时间、MU、ALT和ABW分别增长了77%、2%、12%和-2%。结论 CM和ASC算法都会增加优化时间,前者能改善靶区均匀度,而后者则相反,更高优先级ASC能减少叶片运动路径对计划的影响,显著改善计划复杂度,在不考虑优化时间情况下,同时兼顾计划质量和投照效率,宫颈癌VMAT计划制定时建议CM和ASC参数分别选取off和high,从而平衡临床需求和治疗执行效率。
Application of aperture shape controller and convergence mode in cervical cancer VMAT radiotherapy plan
Objective To investigate the impact of ASC and CM optimization sub algorithms in the Eclipse planning system on the quality and complexity of volume modulated radiotherapy plan for cervical cancer.Methods This study was a retrospective analysis of 30 patients with cervical cancer(stage I-IVA)who were treated at the First People's Hospital of Yibin from July 2021 to July 2023 in the Department of Oncology(Radiation Oncology).The VMAT plans of the selected cases were re-optimized by changing the ASC setting(off,low,moderate,high)and the CM setting(off,on),respectively.The quality of the treatment plan was evaluated using parameters of plan quality and complexity indicators.Results For PTV,there were statistically significant differences(P<0.05)in HI,CI(except for control groups I and V),D2,D50,and D98 compared to when CM was set to off and CM was set to on.When CM was set to off or on,HI,CI,D2,D50 and D98 all show an increasing trend as ASC was set to off,low,moderate,and high.Except for the control groups I and V,I and II,and V and VI,there were statistically significant differences in gut V45(P<0.05).When CM was set to off or on,as the priority of ASC setting increases,gut V45,bladder V50,left and right femoral head V20 and V30 all show an increasing trend.The changes in MU,ALT,ABW,LTMCS,and AMCS had reduced the complexity of the plan.Compared with CM set to off,CM set to on optimized total average time,MU,ALT,and ABW increased by 77%,2%,12%,and-2%,respectively.Conclusion Both CM and ASC algorithms will increase optimization time.The former can improve target uniformity,while the latter is the opposite.Higher priority ASC can reduce the impact of blade motion paths on the plan and significantly improve plan complexity.Without considering optimization time,it is recommended to select off and high parameters for both CM and ASC when developing VMAT plans for cervical cancer,in order to balance clinical needs and treatment execution efficiency.

Aperture shape controllerConvergence modeCervical cancerVolumetric modulated arc therapyPlan complexity

刘阳、杨小妍、邹隐、李先琴、赵海鹰、屈进文

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宜宾市第一人民医院肿瘤科(放疗科),宜宾 644000

孔径形状控制器 收敛模式 宫颈癌 容积旋转调强放疗 计划复杂度

2024

现代仪器与医疗
中国科学器材公司

现代仪器与医疗

影响因子:1.47
ISSN:2095-5200
年,卷(期):2024.30(6)