Effectsof preserving autonomous respiration under general anesthesia versus using laryngeal mask air-way mechanical ventilation on blood gas analysis,inflammation,and stress response in patients under-going tracheal endoscopy
Objective To analyze the effects of preserving autonomous respiration under general anesthesia and mechani-cal ventilation with laryngeal mask airway anesthesia on blood gas analysis,inflammation,and stress response in patients undergo-ing tracheal endoscopy.Methods Patients undergoing tracheal endoscopy at the Fifth People's Hospital of Ganzhou City,Jian-gxi Province,were selected as the main research subjects.The data collection period was from January 2022 to June 2023.A to-tal of 80 patients who met the inclusion criteria were included in the study.According to the random number table method,they were evenly divided into control group and study group in a 1∶1 ratio.Among them,40 patients received general anesthesia with preservation of autonomous respiration and were classified into the control group,while another 40 patients received laryngeal mask airway anesthesia with mechanical ventilation and were classified into the observation group.The anesthesia effects of the two groups were recorded.Blood gas analysis[arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2),arterial oxygen saturation(SaO2)],levels of inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),tumor necrosis factor-alpha(TNF-α)],and stress response[cortisol(Cor),angiotensin-Ⅰ(Ang-Ⅰ)]were analyzed at different time points:before anesthesia(T0),immediately after anesthesia induction(T1),at the start of fiberoptic bronchoscopy exami-nation(T2),and at the end of the examination(T3).Complications occurrence was also recorded during the follow-up period.Results The anesthesia success rate in the observation group was 95.00％,while in the control group,it was 85.00％,with a statistically significant difference between the two groups(P＜0.05).There were no significant differences in PaO2,PaCO2,SaO2,IL-6,PCT,TNF-α,Cor,and Ang-Ⅰ between the two groups at T0(P＞0.05).At T1 and T2,there were no significant changes in PaO2,PaCO2,SaO2,IL-6,PCT,TNF-α,Cor,and Ang-Ⅰ compared to T0(P＞0.05).However,atT3,compared to the control group,the observation group showed statistically significant differences in the above indicators(P＜0.05).There were no significant differences in the occurrence of complications between the two groups during the treatment period(P＞0.05).Conclusion By comparing the clinical effects of preserving autonomous respiration under general anesthesia and laryngeal mask airway anesthesia with mechanical ventilation,it is found that both methods are feasible for use in fiberoptic bronchoscopy exami-nation.However,the latter has less impact on patients'blood gas parameters,inflammation,and stress response,ensuring anes-thesia efficacy while maintaining a certain level of safety,thus having good application value.
Preserving autonomous respiration under general anesthesiaLaryngeal mask airway anesthesia with me-chanical ventilationTracheal endoscopyBlood gas analysisInflammationStress response
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