Objective To analyze the efficacy and safety of Contezolid in patients with non-tuberculous mycobacterium,and explore the methods of clinical application management so as to provide reference for clinical rational application.Methods A case of a patient with non-tuberculous mycobacterium lung disease was analyzed.Adverse reactions such as lower limb numb-ness and decreased heart rate occurred after using common non-tuberculous mycobacterium drugs such as linezolid.Cantizolid was used as one of the new therapeutic drugs to observe the therapeutic effect and adverse reactions.Results It was confirmed that the peripheral neuritis was caused by linezolid.After treatment with contezolid,the symptoms improved,the lung lesions were ab-sorbed,and no adverse reactions occurred.It is necessary to conduct investigator-initiated clinical trials of contezolid and enrich evidence of off-label drug use.Conclusion Contezolid has similar antibacterial activity to linezolid,and the toxic side effects are lower after drug structure modification.Contezolid has a good application prospect in the treatment of non-tuberculous myco-bacterium,and can be used as an alternative to linezolid for long-term use.
ContizolidNon-tuberculous mycobacteriumRational drug useOff-label drug use
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