Objective:To explore the impact of perceived safety atmosphere by healthcare workers in the workplace on patient safety notification willingness,and further explore the influence of self-esteem moderating variables on patient safety notification willingness.Method:A cross-sectional study was conducted on the clinical staff using the patient safety notification system,and SPSS 18.0 was used as statistical software for multiple regression analysis.Result:The perceived safety atmosphere of medical staff and the willingness of patients to report safety had significant effects.The self-esteem of medical staff had a negative correlation with the perception of safety atmosphere and patients'willingness to report safety.Conclusion:Medical staff were willing to report safety under a good perception of safety atmosphere,but medical staff with high self-esteem were unwilling to report safety.Managers can improve medical quality through training,process reengineering and experience sharing,and closely integrate medical care between hospitals,employees and patients to promote patient safety and improve medical treatment level.