非小细胞肺癌程序性死亡配体(PD-L1)表达的临床及CT影像学研究
Clinical and CT Imaging Study of Programmed Death Ligand(PD-L1)Expression in Non-small Cell Lung Cancer
黄锦贤 1代海洋 2汪欣 3尹凯文 2罗欢嘉4
作者信息
- 1. 汕头大学医学院(广东汕头 515000);惠州市第一人民医院放射科(广东惠州 516001)
- 2. 惠州市中心人民医院放射科(广东惠州 516001)
- 3. 惠州市第一人民医院放射科(广东惠州 516001)
- 4. 惠州市中心人民医院超声医学科(广东惠州 516001)
- 折叠
摘要
目的:分析非小细胞肺癌PD-L1表达与患者的临床及CT影像学特征的相关性,揭示肺癌PD-L1表达的预测因子,进而指导临床治疗及患者预后评估.方法:回顾性分析行PD-L1检测108例非小细胞肺癌患者的临床病理及CT影像资料.结果:(1)在肺癌PD-L1阳性(63例)及阴性(45例)两个表达组之间比较,患者年龄、性别、吸烟史、CEA、肺癌分型临床病理特征指标及肺癌影像学征象均无显著差异(P＞0.05);(2)63例肺癌PD-L1阳性表达患者中,在PD-L1阳性高表达组(24例)与低表达组(39例)之间比较,无抽烟史低表达率(82.1％)显著高于有抽烟史的低表达率(17.9％),P=0.039,具有统计学差异.结论:肺癌PD-L1表达与患者抽烟有关,抽烟的患者具有更高的PD-L1表达率;而其余临床特征及肺癌影像征象与其无相关性.
Abstract
Objective:To analyze the correlation between the expression of PD-L1 in non-small cell lung cancer and the clinical and CT imaging features of patients,and to reveal the predictors of PD-L1 expression in lung cancer,so as to guide clinical treatment and prognosis evaluation of patients.Methods:The clinicopathological and CT images of 108 patients with non-small cell lung cancer detected by PD-L1 were analyzed retrospectively.Results:(1)There were no significant differences in age,sex,smoking history,CEA,clinical and pathological characteristics of lung cancer classification and imaging signs of lung cancer between the two groups with positive expression of PD-L1(63 cases)and negative expression of PD-L1(45 cases)(P＞0.05).(2)Among 63 patients with positive expression of PD-L1 in lung cancer,the low expression rate without smoking history(82.1％)was significantly higher than the low expression rate with smoking history(17.9％),P=0.039,with statistical difference.Conclusion:The expression of PD-L1 in lung cancer is related to smoking,and the smoking patients have a higher expression rate of PD-L1.However,the other clinical features and imaging signs of lung cancer have no correlation with it.
关键词
PD-L1/非小细胞肺癌/CT影像学Key words
PD-L1/non-small cell lung cancer/CT imaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据