Mine air pressure system is an important power guarantee for mine production,and its safe and stable operation helps to ensure production efficiency and miners'safety.With the increase of mining depth and the complexity of production technology,the pressure air system faces many challenges.Aiming at the existing problems of the mine compressed air system,this paper puts forward a number of system optimization measures,including pipe network layout optimization,intelligent control of operating parameters and air compressor combination optimization,etc.,and conducts experiments in a coal mine to verify the effectiveness of the optimization measures.The experimental results show that the optimized compressed air system has significant improvement in air supply capacity,air compressor efficiency,pipe network pressure loss,energy consumption and failure rate.These optimization measures not only improve the safety and efficiency of the system,but also provide a new idea for the intelligent development of mines.