Augmented renal clearance in septic patients with antibiotic blood concentration
李子轩 1刘春峰 1林楠
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 中国医科大学附属盛京医院儿童急诊与重症医学科，沈阳 110004
折叠
摘要
肾脏清除率增加（ARC）可以由疾病本身、炎症状态以及治疗干预引起，常见于重症感染与创伤。脓毒症是全球性高发病率、高病死率的重要疾病之一。目前研究认为ARC与脓毒症患者的抗菌药物治疗浓度不足显著相关，增加了临床治疗失败的风险。虽然目前ARC的临床筛查尚不规范，但优化脓毒症ARC患者的给药策略至关重要。本文回顾近年来有关脓毒症患者ARC时抗生素血药浓度变化及给药策略方面的相关内容，以期为ARC患者提供合适的用药与临床指导。 Augmented renal clearance（ARC）can be caused by the disease itself，inflammatory state，or therapeutic interventions，and is often associated with severe infections and trauma.Sepsis is one of the most important diseases with high morbidity and mortality in the world.Current studies suggest that ARC is significantly associated with inadequate antimicrobial therapy concentration in patients with sepsis，increasing the risk of clinical treatment failure.It is important to optimize the drug administration strategy for patients with ARC in sepsis，although the current clinical screening of ARC is not yet perfect.This review summarized the literature on changes in blood concentration of antibiotics and administration strategies in patients with sepsis with ARC，in order to provide appropriate medication and clinical guidance for ARC patients.
Abstract
Augmented renal clearance（ARC）can be caused by the disease itself，inflammatory state，or therapeutic interventions，and is often associated with severe infections and trauma.Sepsis is one of the most important diseases with high morbidity and mortality in the world.Current studies suggest that ARC is significantly associated with inadequate antimicrobial therapy concentration in patients with sepsis，increasing the risk of clinical treatment failure.It is important to optimize the drug administration strategy for patients with ARC in sepsis，although the current clinical screening of ARC is not yet perfect.This review summarized the literature on changes in blood concentration of antibiotics and administration strategies in patients with sepsis with ARC，in order to provide appropriate medication and clinical guidance for ARC patients.
万方数据