Progress on surveillance of Carbapenem-resistant Enterobacteriaceae colonization in children
刘凌 1闫钢风 1陆国平 1李巍
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作者信息
1. 复旦大学附属儿科医院重症医学科，上海 201102
折叠
摘要
碳青霉烯耐药肠杆菌（CRE）是医院感染常见病原菌之一，并在各国广泛传播，成为全球重要的公共卫生问题之一。随着儿童感染患者比例的上升，近年来CRE院感防控的相关研究也更加关注这一群体。由于针对CRE感染的治疗手段十分有限，病死率高，故早期预防尤为重要。主动筛查作为预防CRE感染的核心措施，近年来已在多个国家开展，并被证实对CRE的院内感染防控有积极作用。主动筛查的目标人群一般包括CRE患者密切接触人群以及CRE感染高风险人群；筛查标本多使用肛周拭子或直肠拭子；检测方法包括细菌培养法和分子检测技术，并以前者为主；筛查时机为对新入院患者24 h内留取初次标本，并以定期检测的方式对感染高风险人群进行全程随访。 Carbapenem-resistant Enterobacteriaceae（CRE）is one of the common pathogens of hospital-acquired infections and has been widely spread in various countries，becoming one of the important public health problems worldwide.With the increase in the proportion of pediatric patients with CRE infections，studies related to the prevention and the control of CRE nosocomial infections have focused more on this group in recent years.Early prevention is particularly important because of the very limited treatment options for CRE infections and the high morbidity and mortality rates.Active screening，as a core measure to prevent CRE infection，has been implemented in several countries in recent years and has been shown to have a positive effect on the prevention and control of nosocomial infection in CRE.The target population of active screening generally includes people in close contact with CRE patients and people at high risk of CRE infection；screening specimens are mostly used in perianal swabs or rectal swabs；detection methods include bacterial culture and molecular detection techniques，with the former being the main method；the timing of screening is to collect the initial specimen within 24 hours of new admission，and follow up people at high risk of infection with regular testing.
Abstract
Carbapenem-resistant Enterobacteriaceae（CRE）is one of the common pathogens of hospital-acquired infections and has been widely spread in various countries，becoming one of the important public health problems worldwide.With the increase in the proportion of pediatric patients with CRE infections，studies related to the prevention and the control of CRE nosocomial infections have focused more on this group in recent years.Early prevention is particularly important because of the very limited treatment options for CRE infections and the high morbidity and mortality rates.Active screening，as a core measure to prevent CRE infection，has been implemented in several countries in recent years and has been shown to have a positive effect on the prevention and control of nosocomial infection in CRE.The target population of active screening generally includes people in close contact with CRE patients and people at high risk of CRE infection；screening specimens are mostly used in perianal swabs or rectal swabs；detection methods include bacterial culture and molecular detection techniques，with the former being the main method；the timing of screening is to collect the initial specimen within 24 hours of new admission，and follow up people at high risk of infection with regular testing.
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