Research progress on neutralizing antibodies for the treatment of severe respiratory syncytial virus infection in children
高媛 1李玖军 1林楠
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作者信息
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
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摘要
呼吸道合胞病毒（RSV）是幼儿严重下呼吸道感染的主要病原体之一，RSV感染有较高的住院率和病死率。目前尚未报道有特异性抗RSV疗法。RSV主要由其表面F、G蛋白起到黏附及侵袭宿主细胞的作用。针对具有中和位点的F蛋白及G蛋白的相关单克隆抗体成为研发热点。本文对基于中和抗体抗RSV的机制、相关预防及治疗手段进行综述。 Respiratory syncytial virus（RSV）is the leading cause of severe lower respiratory tract infections in young children，with a high rate of hospitalization and mortality.Specific anti-RSV therapies have not been reported.The structure of RSV is such that it is mainly F and G proteins in the surface that act as adhesion and invade the host cells.Therefore，monoclonal antibodies against F and G proteins with neutralization sites are currently being developed. This review summarized the mechanism, prevention and treatment of RSV based on neutralizing antibody.
Abstract
Respiratory syncytial virus（RSV）is the leading cause of severe lower respiratory tract infections in young children，with a high rate of hospitalization and mortality.Specific anti-RSV therapies have not been reported.The structure of RSV is such that it is mainly F and G proteins in the surface that act as adhesion and invade the host cells.Therefore，monoclonal antibodies against F and G proteins with neutralization sites are currently being developed. This review summarized the mechanism, prevention and treatment of RSV based on neutralizing antibody.
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