首页|Extracellular vesicles as tools and targets in therapy for diseases

Extracellular vesicles as tools and targets in therapy for diseases

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Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular space.They exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological conditions.Human serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses challenges.These vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease biomarkers.Especially in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic biomarkers.Moreover,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical significance.The need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains unfulfilled.Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future.In this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

Mudasir A.Kumar、Sadaf K.Baba、Hana Q.Sadida、Sara Al.Marzooqi、Jayakumar Jerobin、Faisal H.Altemani、Naseh Algehainy、Mohammad A.Alanazi、Abdul-Badi Abou-Samra、Rakesh Kumar、Ammira S.Al-Shabeeb Akil、Muzafar A.Macha、Rashid Mir、Ajaz A.Bhat

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Watson-Crick Centre for Molecular Medicine,Islamic University of Science and Technology,Awantipora,Kashmir 192122,India

Department of Human Genetics-Precision Medicine in Diabetes,Obesity and Cancer Program,Sidra Medicine,Doha,Qatar

Qatar Metabolic Institute,Academic Health System,Hamad Medical Corporation,Doha,Qatar

Department of Medical Laboratory Technology,Prince Fahad Bin Sultan Chair for Biomedical Research,Faculty of Applied Medical Sciences,University of Tabuk,Tabuk,Saudi Arabia

School of Biotechnology,Shri Mata Vaishno Devi University,Katra,India

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Sidra Medicine Research FundSidra Medicine Research FundRamalingaswami Fellowship from the Department of BiotechnologyCore Research Grant from Science and Engineering Research Board,Govt.of India,New DelhiPromotion of University Research and Scientific Excellence(PURSE)Department of Science and Technology,Govt.of India,New Delhi,to the Islamic University of Science and Technology(IUST),AwantOpen Access funding provided by the Qatar National Library

SDR400105SDR400175D.O.BT/HRD/35/02/2006CRG/2021/003805SR/PURSE/2022/121

2024

10.1038/s41392-024-01735-1

信号转导与靶向治疗(英文)

信号转导与靶向治疗(英文)

CSTPCD
ISSN：
年,卷(期)：2024.9(3)
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