首页|Major depressive disorder:hypothesis,mechanism,prevention and treatment

Major depressive disorder:hypothesis,mechanism,prevention and treatment

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Worldwide,the incidence of major depressive disorder(MDD)is increasing annually,resulting in greater economic and social burdens.Moreover,the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear,and additional diagnostic and therapeutic strategies for MDD still are needed.The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis,hypothalamic-pituitary-adrenal(HPA)axis hypothesis,cytokine hypothesis,neuroplasticity hypothesis and systemic influence hypothesis,but these hypothesis cannot completely explain the pathological mechanism of MDD.Even it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD,thus in recent years,great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies,further revealing the disease features of MDD.Furthermore,some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention,some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive symptoms.In this work,we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD,preventive approaches and therapeutic medicines,as well as the related clinical trials.

Lulu Cui、Shu Li、Siman Wang、Xiafang Wu、Yingyu Liu、Weiyang Yu、Yijun Wang、Yong Tang、Maosheng Xia、Baoman Li

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Department of Forensic Analytical Toxicology,School of Forensic Medicine,China Medical University,Shenyang,China

Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences,Shenyang,China

China Medical University Centre of Forensic Investigation,Shenyang,China

International Joint Research Centre on Purinergic Signalling/Key Laboratory of Acupuncture for Senile Disease(Chengdu University of TCM),Ministry of Education/School of Health and Rehabilitation,Chengdu University of Traditional Chinese Medicine/Acupuncture and Chronobiology Key Laboratory of Sichuan Province,Chengdu,China

Department of Orthopaedics,The First Hospital,China Medical University,Shenyang,China

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国家自然科学基金国家自然科学基金Shenyang Science and Technology Innovation Talents Project'ChunHui'Program of Education MinistryNational Natural Science Foundation of China-Russian Science Foundation(NSFC-RSF)Sichuan Provincial Administration of Traditional Chinese Medicine

3227103881871852RC2102512020703822611385572023zd024

2024

10.1038/s41392-024-01738-y

信号转导与靶向治疗(英文)

信号转导与靶向治疗(英文)

CSTPCD
ISSN：
年,卷(期)：2024.9(3)
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