首页|NF-κB in biology and targeted therapy:new insights and translational implications
NF-κB in biology and targeted therapy:new insights and translational implications
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NF-κB signaling has been discovered for nearly 40 years.Initially,NF-KB signaling was identified as a pivotal pathway in mediating inflammatory responses.However,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment options.In this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB signaling.We investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-p,Wnt,Notch,Hedgehog,and TLR signaling.The physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also explicated.Additionally,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and COVID-19.Further,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKIs,non-coding RNAs,immunotherapy,and CAR-T.Finally,we provide an outlook for research in the field of NF-κB signaling.We hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.
Department of Medical Oncology,Fudan University Shanghai Cancer Center,No.270,Dong'an Road,Shanghai 200032,China
Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,China
State Key Laboratory of Oncogenes and Related Genes,Renji-Med-X Stem Cell Research Center,Shanghai Cancer Institute &Department of Urology,Ren Ji Hospital,School of Medicine and School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200127,PR China
Department of Cardiology,the First Affiliated Hospital of Sun Yat-Sen University,58 Zhongshan 2nd Road,Guangzhou 510080,China
Department of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
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国家自然科学基金国家自然科学基金Project of Shanghai Municipal Health CommissionCSCO-ROCHE Cancer Research Fund(2019)Chinese Young Breast Experts Research ProjectBeijing Science and Technology Innovation Medical Development Foundation Key Project
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