首页|Harnessing innate immune pathways for therapeutic advancement in cancer

Harnessing innate immune pathways for therapeutic advancement in cancer

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The innate immune pathway is receiving increasing attention in cancer therapy.This pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal cells.Agonists targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TTME)and improved tumor prognosis in preclinical studies.However,to date,the clinical success of drugs targeting the innate immune pathway remains limited.Interestingly,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor progression.The uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate investigation.In this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell types.We propose that within the TME,the innate immune pathway exhibits multidimensional diversity.This diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling networks.The pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative pathways.Refining our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinical application.

Ankang Hu、Li Sun、Hao Lin、Yuheng Liao、Hui Yang、Ying Mao

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Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai,P.R.China

lnstitute for Translational Brain Research,Shanghai Medical College,Fudan University,Shanghai,P.R.China

National Center for Neurological Disorders,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai,P.R.China

Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration,Shanghai Clinical Medical Center of Neurosurgery,Neurosurgical Institute of Fudan University,Huashan Hospital,Shanghai Medical Co

Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration,Shanghai Clinical Medical Center of Neurosurgery,Neurosurgical Institute of Fudan University,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai,P.R.China

State Key Laboratory of Medical Neurobiology and MOE Frontiers

Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education),and Molecular and Cell Biology Lab,Institutes of Biomedical Sciences,Shanghai Medical College of Fudan University,Shanghai,P.R.China

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国家重点研发计划国家重点研发计划国家自然科学基金国家自然科学基金Central Guidance Funds for Local Science and Technology Development

2023YFC34048002020YFA08042008207316682273203YDZX20233100001003

2024

10.1038/s41392-024-01765-9

信号转导与靶向治疗(英文)

信号转导与靶向治疗(英文)

CSTPCD
ISSN：
年,卷(期)：2024.9(4)
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