首页|RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells.Relevant studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of therapeutics.As a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular phenotypes.To be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts.In this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1 A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(ψ),adenosine-to-inosine(A-to-I)editing,which are relatively the most studied types.Then regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial metabolism.And we highlight the regulation of RNA modifications on immunometabolism,further influencing immune responses.Above all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNA-targeted therapeutics.Eventually,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

Wei-Wei Liu、Si-Qing Zheng、Tian Li、Yun-Fei Fei、Chen Wang、Shuang Zhang、Fei Wang、Guan-Min Jiang、Hao Wang

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Department of Laboratory Medicine,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China

School of Clinical Medicine,Shandong University,Jinan,China

Core Unit of National Clinical Research Center for Laboratory Medicine,Hefei,China

Neurosurgical Department,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China

Department of Clinical Laboratory,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai,China

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Scientific Research Project of Anhui Provincial Education Department安徽省自然科学基金

2022AH0200792008085MH241

2024

10.1038/s41392-024-01777-5

信号转导与靶向治疗(英文)

信号转导与靶向治疗(英文)

CSTPCD
ISSN：
年,卷(期)：2024.9(4)
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