首页|Mitochondrial dysfunction:mechanisms and advances in therapy

Mitochondrial dysfunction:mechanisms and advances in therapy

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Mitochondria,with their intricate networks of functions and information processing,are pivotal in both health regulation and disease progression.Particularly,mitochondrial dysfunctions are identified in many common pathologies,including cardiovascular diseases,neurodegeneration,metabolic syndrome,and cancer.However,the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to diseases.Nonetheless,these complexities do not prevent mitochondria from being among the most important therapeutic targets.In recent years,strategies targeting mitochondrial dysfunction have continuously emerged and transitioned to clinical trials.Advanced intervention such as using healthy mitochondria to replenish or replace damaged mitochondria,has shown promise in preclinical trials of various diseases.Mitochondrial components,including mtDNA,mitochondria-located microRNA,and associated proteins can be potential therapeutic agents to augment mitochondrial function in immunometabolic diseases and tissue injuries.Here,we review current knowledge of mitochondrial pathophysiology in concrete examples of common diseases.We also summarize current strategies to treat mitochondrial dysfunction from the perspective of dietary supplements and targeted therapies,as well as the clinical translational situation of related pharmacology agents.Finally,this review discusses the innovations and potential applications of mitochondrial transplantation as an advanced and promising treatment.

Yao Zong、Hao Li、Peng Liao、Long Chen、Yao Pan、Yongqiang Zheng、Changqing Zhang、Delin Liu、Minghao Zheng、Junjie Gao

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Centre for Orthopaedic Research,Medical School,The University of Western Australia,Nedlands,WA 6009,Australia

Department of Orthopaedics,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China

Institute of Microsurgery on Extremities,and Department of Orthopedic Surgery,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China

State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,CAS Center for Excellence In Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China

Sixth People's Hospital Fujian,No.16,Luoshan Section,Jinguang Road,Luoshan Street,Jinjiang City,Quanzhou,Fujian,China

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National Natural Science Foundation of ChinaShanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System

82002339BJ1-9000-22-4002

2024

10.1038/s41392-024-01839-8

信号转导与靶向治疗(英文)

信号转导与靶向治疗(英文)

CSTPCD
ISSN：
年,卷(期)：2024.9(6)