Open Access Publication Fund of the University of Freiburg enabled and organized by Projekt DEALIMMediate Advanced Clinician Scientist-Program,Department of Medicine Ⅱ,Medical Center,University of Freiburg and Faculty ofBundesministerium für Bildung und Forschung(Federal Ministry of Education and Research)Fritz Thyssen FoundationGerman Research FoundationGerman Research FoundationOpen Access funding enabled and organized by Projekt DEAL