Circulating tumor cells:from new biological insights to clinical practice

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外文摘要：The primary reason for high mortality rates among cancer patients is metastasis,where tumor cells migrate through the bloodstream from the original site to other parts of the body.Recent advancements in technology have significantly enhanced our comprehension of the mechanisms behind the bloodborne spread of circulating tumor cells(CTCs).One critical process,DNA methylation,regulates gene expression and chromosome stability,thus maintaining dynamic equilibrium in the body.Global hypomethylation and locus-specific hypermethylation are examples of changes in DNA methylation patterns that are pivotal to carcinogenesis.This comprehensive review first provides an overview of the various processes that contribute to the formation of CTCs,including epithelial-mesenchymal transition(EMT),immune surveillance,and colonization.We then conduct an in-depth analysis of how modifications in DNA methylation within CTCs impact each of these critical stages during CTC dissemination.Furthermore,we explored potential clinical implications of changes in DNA methylation in CTCs for patients with cancer.By understanding these epigenetic modifications,we can gain insights into the metastatic process and identify new biomarkers for early detection,prognosis,and targeted therapies.This review aims to bridge the gap between basic research and clinical application,highlighting the significance of DNA methylation in the context of cancer metastasis and offering new avenues for improving patient outcomes.

作者：

Xuyu Gu、Shiyou Wei、Xin Lv

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作者单位：

Department of Oncology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China

Department of Anesthesiology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China

基金：

National Natural Science Foundation of ChinaProject of Key Supported Disciplines by Shanghai Municipal Health CommissionProgram of Shanghai Academic Research LeaderDevelopment Fund for the Department of Anesthesiology,Shanghai Pulmonary Hospital

项目编号：

823721552023ZDFC020421XD1402800

出版年：

2024

DOI：

10.1038/s41392-024-01938-6

信号转导与靶向治疗(英文)

CSTPCD

ISSN：

年,卷(期)：2024.9(10)