Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges

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外文摘要：Over the past two decades,mesenchymal stem/stromal cell(MSC)therapy has made substantial strides,transitioning from experimental clinical applications to commercial products.MSC therapies hold considerable promise for treating refractory and critical conditions such as acute graft-versus-host disease,amyotrophic lateral sclerosis,and acute respiratory distress syndrome.Despite recent successes in clinical and commercial applications,MSC therapy still faces challenges when used as a commercial product.Current detection methods have limitations,leaving the dynamic biodistribution,persistence in injured tissues,and ultimate fate of MSCs in patients unclear.Clarifying the relationship between the pharmacokinetic characteristics of MSCs and their therapeutic effects is crucial for patient stratification and the formulation of precise therapeutic regimens.Moreover,the development of advanced imaging and tracking technologies is essential to address these clinical challenges.This review provides a comprehensive analysis of the kinetic properties,key regulatory molecules,different fates,and detection methods relevant to MSCs and discusses concerns in evaluating MSC druggability from the perspective of integrating pharmacokinetics and efficacy.A better understanding of these challenges could improve MSC clinical efficacy and speed up the introduction of MSC therapy products to the market.

作者：

Yunlong Shan、Mengying Zhang、Enxiang Tao、Jing Wang、Ning Wei、Yi Lu、Qing Liu、Kun Hao、Fang Zhou、Guangji Wang

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作者单位：

Key Laboratory of Drug Metabolism and Pharmacokinetics,Haihe Laboratory of Cell Ecosystem,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing,China

Jiangsu Renocell Biotech Co.Ltd.,Nanjing,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaLeading Technology Foundation Research Project of Jiangsu ProvinceHaihe Laboratory of Cell Ecosystem Innovation FundNanjing Scientific and Technological Special Project for Life and Healththe"Double First-Class"University Projectthe"Double First-Class"University ProjectJiangsu Province"333"project,ChinaFundamental Research Funds for the Central Universities

项目编号：

821041848207392882373949BK2019200522HHXBSS00005202110006CPU2018GF01China2632023TD03

出版年：

2024

DOI：

10.1038/s41392-024-01936-8

信号转导与靶向治疗(英文)

CSTPCD

ISSN：

年,卷(期)：2024.9(10)