首页|Pre-metastatic niche:formation,characteristics and therapeutic implication
Pre-metastatic niche:formation,characteristics and therapeutic implication
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Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes in cancer patients.Before the development of organ-specific metastasis,the formation of a pre-metastatic niche is pivotal in promoting the spread of cancer cells.This review delves into the intricate landscape of the pre-metastatic niche,focusing on the roles of tumor-derived secreted factors,extracellular vesicles,and circulating tumor cells in shaping the metastatic niche.The discussion encompasses cellular elements such as macrophages,neutrophils,bone marrow-derived suppressive cells,and T/B cells,in addition to molecular factors like secreted substances from tumors and extracellular vesicles,within the framework of pre-metastatic niche formation.Insights into the temporal mechanisms of pre-metastatic niche formation such as epithelial-mesenchymal transition,immunosuppression,extracellular matrix remodeling,metabolic reprogramming,vascular permeability and angiogenesis are provided.Furthermore,the landscape of pre-metastatic niche in different metastatic organs like lymph nodes,lungs,liver,brain,and bones is elucidated.Therapeutic approaches targeting the cellular and molecular components of pre-metastatic niche,as well as interventions targeting signaling pathways such as the TGF-β,VEGF,and MET pathways,are highlighted.This review aims to enhance our understanding of pre-metastatic niche dynamics and provide insights for developing effective therapeutic strategies to combat tumor metastasis.
Department of Colorectal Surgery,The First Affiliated Hospital of Zhengzhou University,1 East Jianshe Road,Zhengzhou 450000,China
College of Medicine,Zhengzhou University,Zhengzhou 450001,China
Henan Medical Science and Technology Research PlanChina Postdoctoral Science FoundationNational funded postdoctoral researcher programProvincial and Ministry Coconstructed Key Projects of Henan Medical Science and Technology
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