Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetric & Gynecologic Diseases,the State Key Laboratory for Complex,Severe,and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

State Key Laboratory of Common Mechanism Research for Major Diseases,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing,China