中低位直肠癌的精准诊断与规范治疗

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中文摘要：结直肠癌是我国主要消化系统疾病,并以中低位直肠癌为主.经过数十年发展,我国结直肠外科取得长足进步,在临床诊断与治疗、科研探索和数据平台建设等方面,均取得一定建树,但仍需提高诊断的精准度与治疗的规范化.此外,以程序性死亡受体1为代表的免疫检查点治疗,在中低位直肠癌治疗中初显成效,需进一步探索免疫检查点抑制剂与传统放化疗之间的关系和作用,将之转化为精准的临床实践.笔者深入阐述我国中低位直肠癌的诊断与治疗现状,以期为直肠癌精准诊断与规范治疗提供参考.

外文标题：Precision diagnosis and standardized treatment of mid-low rectal cancer

外文摘要：Colorectal cancer is a major digestive disease in China,with mid-low rectal cancer as the predominant cause.Over the years,Chinese colorectal surgery has made considerable strides,attaining certain successes in clinical diagnosis and treatment,scientific research,and data platform construction.Nevertheless,there is still room for improvement in terms of the accuracy of diagnosis and standardization of treatment.Furthermore,immune checkpoint therapy represented by programmed death-1 have demonstrated initial efficacy in the treatment of mid-low rectal cancer.Further research is required to better understand the relationship and role between immune checkpoint inhibitors and traditional radiotherapy and chemotherapy,and to apply them to precise clinical practice.The authors elaborate on current status of diagnosis and treatment for mid-low rectal cancer in China,in order to provide references for its precission diagnosis and standardized treatment.

外文关键词：

Rectal neoplasmsChinese colorectal cancer surgery databaseChinese trans-anal total mesorectal excision registry collaborativeImmunotherapyNeo-adjuvant therapyMagnetic resonance imaging

作者：

杨鋆、辛城霖、张忠涛

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作者单位：

首都医科大学附属北京友谊医院普通外科中心国家消化系统疾病临床医学研究中心消化健康全国重点实验室,北京 100050

关键词：

直肠肿瘤中国结直肠癌手术病例登记数据库中国经肛全直肠系膜切除病例登记协作研究免疫治疗新辅助治疗磁共振成像

基金：

国家科技支撑计划国家重点研发计划北京市临床重点专科基金卓越项目北京市自然科学基金海淀原始创新联合基金北京市属医院科研培育项目首都医科大学结直肠肿瘤临床诊疗与研究中心基金

项目编号：

2015BAI13B092017YFC01109042018-118L222149PX20220021192070313

出版年：

2024

DOI：

10.3760/cma.j.cn115610-20231211-00248

中华消化外科杂志

中华医学会

中华消化外科杂志

CSTPCD北大核心

影响因子：1.899

ISSN：1673-9752

年,卷(期)：2024.23(1)

参考文献量11