三级淋巴结构在胰腺癌的临床应用价值和研究展望
Clinical application value and research prospects of tertiary lymphoid structures in pancreatic cancer
杨尹默 1张恩魁 1马永蔌 1朱昱1
作者信息
- 1. 北京大学第一医院肝胆胰外科,北京 100034
- 折叠
摘要
特殊的抑制性肿瘤免疫微环境是胰腺癌术后复发率高且对免疫治疗不敏感的重要原因.三级淋巴结构(TLSs)是由多种免疫细胞组成的病理性异位淋巴组织,在调节适应性抗肿瘤免疫过程中扮演重要角色.胰腺癌组织中存在TLSs预示更好的预后和免疫治疗反应.检测TLSs在胰腺癌标本中的数量、位置、成熟度和细胞组分有助于判断胰腺癌预后,筛选免疫治疗潜在获益人群.探索诱导TLSs形成的关键因素,解析TLSs抗肿瘤免疫机制可能为提高胰腺癌免疫治疗疗效提供新的理论基础.笔者总结TLSs在胰腺癌应用的临床现状和热点问题,展望TLSs在胰腺癌领域的研究方向.
Abstract
The special suppressive tumor immune microenvironment is a significant factor in the high postoperative recurrence rate and insensitivity to immunotherapy in pancreatic cancer.Tertiary lymphoid structures(TLSs)are pathologic ectopic lymphoid tissues composed of various immune cells,playing a crucial role in regulating adaptive anti-tumor immune responses.The presence of TLSs in pancreatic cancer tissues signifies better prognosis and immune therapy response.Examining the quantity,location,maturity,and cellular components of TLSs in pancreatic cancer specimens helps predict prognosis and screen potential beneficiaries of immunotherapy.Exploring key factors inducing TLSs formation and elucidating the anti-tumor immune mechanisms of TLSs may provide a new theoretical basis for enhancing the efficacy of pancreatic cancer immunotherapy.The authors summarize the clinical status and hot topics of TLSs in pancreatic cancer applications,and look forward to the research directions of TLSs in the field of pancreatic cancer.
关键词
胰腺肿瘤/三级淋巴结构/免疫治疗/肿瘤微环境/应用与展望Key words
Pancreatic neoplasms/Tertiary lymphoid structures/Immunotherapy/Tumor microenvironment/Application and prospects引用本文复制引用
基金项目
国家自然科学基金(82171722)
国家自然科学基金(82271764)
出版年
2024
NETL
NSTL
万方数据