Objective To investigate the clinical effect of Tongguanteng oral liquid combined with docetaxel(DXT)and nedaplatin(NDP)regimen in the treatment of middle and advanced esophageal cancer.Method 64 patients with middle and advanced esophageal cancer admitted to the First Affiliated Hospital of Second Military Medical University of the People's Liberation Army during February 2020 to March 2023 were selected.They were divided into chemotherapy group(n=32)and comprehensive group(n=32)using the random number table method.The chemotherapy group was treated with DXT-NDP regimen,and the comprehensive group was treated with Tongguanteng oral liquid combined with DXT-NDP regimen.Both groups received treatment for 2 consecutive cycles.The clinical efficacy,Traditional Chinese medicine(TCM)syndrome score,cellular immune function,quality of life and toxic side effects were compared between the 2 groups.Result The objective remission rate of the comprehensive group was higher than that of the chemotherapy group(P＜0.05).After treatment,the scores of TCM syndrome of main disease,secondary disease and total score decreased in 2 groups,while the sores of comprehensive group were lower(P＜0.05).There was no statistical difference in CD8+T cells level between the 2 groups before and after treatment(P＞0.05).Compared with before treatment,the levels of CD4+T cells,CD4+/CD8+,CD3-CD16+CD56+and CD3+CD16+CD56+natural killer cells were increased in 2 groups after treatment,and the levels of comprehensive group were higher than those of chemotherapy group at the same time point after treatment(P＜0.05).After treatment,the scores of Kamofsky performance scale and quality of life questionnaire-C30 in 2 groups were higher than those before treatment,while the sores of comprehensive group were higher than those of chemotherapy group at the same time point after treatment(P＜0.05).Compared with chemotherapy group,the incidence of grade Ⅰ+Ⅱgastrointestinal reaction,liver and kidney function injury,myelosuppression,and the total incidence of liver and kidney function injury and gastrointestinal reaction were lower in comprehensive group(P＜0.05).Conclusion The application of Tongguanteng oral liquid combined with DXT-NDP regimen in the treatment of middle and advanced esophageal cancer can significantly improve the curative effect,alleviate clinical symptoms,improve the immune function of the body,thus improve the quality of life of patients,and reduce the occurrence of toxic side effects.
维普
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