长链非编码RNA在食管鳞状细胞癌中调控转录、翻译及翻译后修饰的相关机制研究进展
Research progress on the mechanisms of transcription,translation and post-translation modification of long non-coding RNA in esophageal squamous cell carcinoma
宗煜煜 1陈琳徽 1罗鹏飞 1江拥军1
作者信息
- 1. 永州市中心医院 肿瘤科,湖南 永州 425000
- 折叠
摘要
食管癌是一种常见的消化道恶性肿瘤,发病率和死亡率均较高,且整体预后较差.食管癌病理类型主要有鳞状细胞癌和腺癌两种,西方国家以腺癌为主,我国与其相反,主要为食管鳞状细胞癌.由于早期症状不典型以及缺乏特异的肿瘤标志物,许多患者在中晚期才确诊,治疗效果欠佳,导致 5 年生存率仍非常低.长链非编码RNA(long non-coding RNA,LncRNA)与食管癌的发生发展密不可分,当务之急是需要深入探索LncRNA在食管癌中的作用,开发出更多的治疗靶点以提高其 5 年生存率.基于此,本文着重阐述了LncRNA在食管鳞状细胞癌中的作用机制,明确其如何调节食管鳞状细胞癌的发生发展,探讨它作为诊断和预后生物标志物的潜在临床价值,为临床治疗提供思路.
Abstract
Esophageal cancer is a common malignant digestive tract tumors,with high morbidity and mortality,and poor prognosis.There are two main pathological types of esophageal cancer:squamous cell carcinoma and adenocarcinoma.Adenocarcinoma is the main pathological type in Western countries,while esophageal squamous cell carcinoma(ESCC)is the main pathological type in China.Due to the atypical early symptoms and lack of specific tumor markers in the early stage,many patients are diagnosed in the middle and late stages,and the treatment effect is poor,resulting in a very low five-year survival rate.Long non-coding RNA(LncRNA)is closely related to the occurrence and development of esophageal cancer.Therefore,it is urgent for us to explore the role of LncRNA in esophageal cancer and develop more therapeutic targets to improve its five-year survival rate.Based on this,this article focuses on the mechanism of LncRNA in ESCC,clarify how it regulates the occurrence and development of ESCC,explore its potential clinical value as a diagnostic and prognostic biomarker,and provide ideas for clinical treatment.
关键词
食管鳞状细胞癌/长链非编码RNA/转录/翻译/生物标志物/作用机制Key words
Esophageal squamous cell carcinoma/Long non-coding RNA/Transcription/Translation/Biomarker/Mechanism引用本文复制引用
基金项目
湖南省卫生健康委科研项目(202202085648)
出版年
2024
NETL
NSTL
万方数据