Gastric cancer(GC)is the fifth morbidity and the fourth mortality of cancer in the world.The incidence of GC in China ranks first in the world.GC has the characteristics of occult onset,strong heterogeneity and poor prognosis.Majority patients are first diagnosed in the advanced stage.Drugs are the main treatment method for GC and a hot spot of GC research.In recent years,with the rapid progress of immunotherapy and targeted therapy,the drug therapy has made many breakthroughs.However,we are facing multiple challenges about it.We reviewed the progress and breakthrough made in the field of immunotherapy and targeted therapy for GC in 2023-2024,and put forward the difficulties and challenges currently in order to provide ideas and suggestions for further exploration of drug therapy for GC in future.
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