In recent years,immune checkpoint inhibitor has been widely used in solid tumors.Especially colorectal cancer patients with high microsatellite instability,have derived much benefit.However,80%to 90%of colorectal cancer patients with microsatellite stabilization are not sensitive to immunotherapy based on single immune checkpoint inhibitor.Therefore,through combining immune checkpoint inhibitor with traditional chemotherapy or targeted therapy,which might reverse the immunosuppressive microenvironment of stable microsatellite colorectal cancer;or screening stable microsatellite patients who are sensitive to immune checkpoint inhibitors through effective biomarkers,were the main directions to deal with this dilemma.This article will discuss the current research status of immunotherapy for advanced colorectal cancer from the above issues.
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