Objective To investigate the association between the C677T polymorphism of methylenetetrahydrofolate reductase(MTHFR)gene and the risk of colorectal cancer(CRC).Method From January 2022 to December 2023,101 cases of CRC patients diagnosed in Chaozhou People's Hospital were selected as the study group,and 98 healthy persons were included as the control group.The MTHFR C677T polymorphism of the subjects was detected by polymerase chain reaction and Sanger sequencing.The differences of the data between the two groups,such as age,gender,body mass index,smoking history,drinking history,family history and genotype were compared.Multifactorial Logistic regression model was used to calculate the adjusted odds ratio(AOR)and 95%CI,and to evaluate the risk factors for CRC.Result The differences in genotype and allele distribution of the MTHFR C677T locus between the study group and control group were statistically significant(both P<0.05).The results of multifactorial Logistic regression model analysis showed that the risk of CRC incidence was higher in CC and CT genotypes than that in TT genotypes(AOR=4.068,95%CI 1.672-9.896,P<0.05;AOR=2.866,95%CI 1.481-5.546,P<0.05),and the risk of CRC incidence in people with C allele homozygote(CC)was higher than that with T allele(CT+TT)(AOR=3.176,95%CI 1.718-5.870,P<0.05).Conclusion The CC genotype and C allele of the C677T locus of MTH FR gene may increase the risk of CRC incidence.
维普
万方数据