Objective Compare the prognosis of gastric adenocarcinoma patients with peritoneal metastasis and malignant bowel obstruction who underwent chemotherapy versus conservative treatment,in order to analyze the effectiveness of chemotherapy.Method This retrospective study screened all cases of gastric adenocarcinoma with peritoneal metastasis and malignant bowel obstruction admitted to the Sixth Affiliated Hospital of Sun Yat-sen University from January 2013 to December 2021.Patients were divided into a conservative treatment group and a chemotherapy group based on whether chemotherapy was administered after diagnosis of malignant bowel obstruction.Using propensity score matching,and pairing in a 1∶1 ratio,the obstruction clearance rates,one-month mortality rates,and overall survival time of the two groups were compared and analyzed.Result After matching 71 pairs of patients,the baseline characteristics of the matched groups were comparable.The obstruction clearance rate of patients in the conservative treatment group was 31.0%,with a one-month mortality rate of 16.9%and a median overall survival time of 1.87 months.The obstruction clearance rate of patients in the chemotherapy group was 76.1%,with a one-month mortality rate of 7.0%and a median overall survival time of 6.73 months.Compared to the conservative treatment group,the chemotherapy group had a higher obstruction clearance rate,a lower one-month mortality rate,and a longer median overall survival time,with all differences being statistically significant(P＜0.05).Conclusion For gastric adenocarcinoma patients with peritoneal metastasis and malignant bowel obstruction,chemotherapy is an effective treatment option and plays a crucial role in cancer therapy.
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