Objective This article aims to analyze the factors affecting early ambulation of patients after gastrointestinal tumor surgery through systematic review.Method We conducted literature search in Chinese and English databases,including CNKI,Chinese Science and Technology Journal Database,Wanfang Data Knowledge Service Platform,PubMed,Scopus,and EBSCO for relevant studies on the factors affecting early ambulation of patients after gastrointestinal tumor surgery.The search period is from database establishment to January 2024.Screened relevant research literatures according to inclusion and exclusion criteria.The cross-sectional study quality evaluation tool recommended by the American Agency for Healthcare Research and Quality was used to evaluate the quality of the included literatures.RevMan 5.3 software was applied for Meta-analysis.The impact of patient factors,preoperative factors,surgical factors,and postoperative factors on the early ambulation of patients after gastrointestinal tumor surgery were evaluated.Result 8 studies were included,and their quality grading were grade A or B.The Meta-analysis results showed that the influencing factors conducive to early ambulation included patients'age<70 years old(OR=2.16,95%CI 1.11-4.21,P=0.02),male(OR=1.72,95%CI 1.30-2.28,P=0.0002),and the number of indwelling catheters<4(OR=3.24,95%CI 1.19-8.85,P=0.02).Conclusion The influencing factors of early ambulation in patients after gastrointestinal tumor surgery included age,gender,and the number of indwelling catheters after surgery.Paying attention to these influencing factors can help formulate personalized perioperative nursing plans for patients and promote their rapid recovery.