The initial building and application of the DNA specimen database in Uygur Chinese population with depression
Objective To built up the normative DNA specimen bank of Uyghur population with depression initially,and to analyze the polymorphism of TPH-2 gene.Methods 800 Uyghur patients with depression were collected by the demography,clinical data and DNA specimens from January,2010 to January 2013. After quality control,DNA specimens were retained in the vital diseases repository of the first Affiliated Hospital to Xinjiang Medical University,then we set up the clinical data repository,and assessed the pos-sible risk factors of the disease.According to direct DAN sequencing ,we investigated the association be-tween the polymorphism of TPH-2 gene and suicidal tendencies of depression.Results (1)The result of preliminary application shows that 99.6% of samples were genotyped successfully for rs7305115.(2)The significant differences of HAMD-1 7 scores were found between groups with different educational back-ground or professions (P <0.05).(3)The scores of HAMD-17 had no differences statistically among dif-ferent genotypes(A/A,A/G,G/G)(all P >0.05).(4)rs7305115 was not found to have genotypic or al-lelic association with suicidal tendencies between the cases with suicide intension and those without (P >0.05).Conclusion The normative DNA specimen database of Uyghur population with depression was built up initially.Literacy level and social status were associated with the condition of the disease.But it failed to find the correlation between TPH-2 gene and depression.
NETL
NSTL
万方数据
维普
