PAI-1单核苷酸多态性与结直肠癌发生风险的相关性研究
Correlation between PAI-1 single nucleotide polymorphism and risk of colorectal cancer
靳志雄 1胡常晖 2张建军 3李蕊4
作者信息
- 1. 张家口市第一医院胃肠外科
- 2. 张家口市第一医院肾内科
- 3. 张家口市第一医院急诊科
- 4. 河北北方学院附属第一医院骨外科,河北 张家口 075000
- 折叠
摘要
目的 研究纤溶酶原激活物抑制剂-1(Plasminogen activator inhibitor-1,PAI-1)基因单核苷酸多态性与结直肠癌发生风险的相关性.方法 以2019年5月-2021年5月张家口市第一医院胃肠外科收治的120例结直肠癌患者为病例组,另取同期80例健康体检者为对照组.检测两组受试者血清中PAI-15G/5G、4G/5G、4G/4G基因型及等位基因表达情况,分析不同基因型与结直肠癌发生风险的相关性.结果 与对照组比较,病例组4G/4G基因型和4G等位基因占比增加(x2=10.920,P=0.001;x2=13.230,P＜0.001).4G/4G型基因携带者患结直肠癌的危险性是5G/5G型基因携带者的5.227倍(x2=10.920,P=0.001),4G型基因携带者患结直肠癌的危险性是5G型基因携带者的2.254倍(x2=13.230,P＜0.001).Logistic回归模型分析显示PAI-1基因型(OR=5.039,P=0.003)与结直肠癌的发生显著相关.PAI-1基因型与肿瘤分期(x2=6.311,P=0.043)、淋巴结转移(x2=14.070,P=0.001)和远处转移(x2=22.470,P＜0.001)存在显著相关性.结论 PAI-1 4G等位基因在结直肠癌患者血清中表达明显增多,可作为预测结直肠癌发生的指标,可用于评估患者预后.
Abstract
Objective The correlation between the single nucleotide polymorphism of Plasminogen activator inhibitor-1(PAI-1)gene and the risk of colorectal cancer.Methods The case group comprised 120 pa-tients with colorectal cancer admitted to the hospital from May 2019 to May 2021,while the control group consisted of 80 healthy subjects undergoing physical examinations during the same period.The genotypes and allele expression of PAI-1 5G/5G,4G/5G and 4G/4G in the serum of the 2 groups were examined,and the correlation between different genotypes and the risk of colorectal cancer was analyzed.Results Compared to control group,the proportion of the 4G/4G genotype and 4G allele in the case group was increased sig-nificantly(x2=10.920,P=0.001;x2=13.230,P＜0.001).The risk of developing colorectal cancer in 4G/4G genotype carriers was 5.227 times that of 5G/5G genotype carriers(x2=10.920,P=0.001),and the risk of developing colorectal cancer in 4G allele carriers was 2.254 times that of 5G allele carriers(x2=13.230,P＜0.001).Logistic regression analysis showed that the PAI-1 genotype(OR=5.039,P=0.003)was significantly associated with colorectal cancer.There was also a significant correlation between PAI-1 gene polymorphism and tumor stage(x2=6.311,P=0.043),lymph node metastasis(x2=14.070,P=0.001)and distant metastasis(x2=22.470,P＜0.001).Conclusion The expression of the PAI-1 4G allele in the serum of patients with colorectal cancer is significantly increased,which can be used as an in-dicator for predicting the occurrence of colorectal cancer and assessing patient prognosis.
关键词
纤溶酶原激活物抑制剂-1/结直肠癌/易感性/预后Key words
plasminogen activator inhibitor-1/colorectal cancer/susceptibility/prognosis引用本文复制引用
基金项目
河北省医学科学研究课题计划项目(20232074)
出版年
2023
NETL
NSTL
维普
万方数据