Prospective cohortstudy of clinical characteristics,DVH parameters and serum cytokines predicting onset ofacute radiation enteritis in patients with cervical cancertreated with radiotherapy
Objective To investigate the predictive effects of clinical characteristics,dose volume histogram(DVH)parameters and pre-radiotherapy serum cytokine levels on acute radiation enteritis(ARE)in pa-tients with cervical cancer treated with radiotherapy.Methods 48 patients with cervical cancer who under-went radiotherapy from March 2022 to December 2022 in the hospital were enrolled.The DVH parame-ters,clinical characteristics(age,BMI,disease stage,pathological type,etc.)of the patients were recor-ded,and venous blood samples before and after the radiotherapy were collected to examine the plasma cy-tokines level(IL-4,IL-6,IL-10,IL-12p70,IL-12p70 and IL12p70)using multi-beads flow fluorescence technology.The incidence of ARE among the groups was compared.The DVH parameters and cytokine levels were compared between the ARE group and the non-ARE group.Logistic regression was used to screen the factors that related to the occurrence of ARE.Receiver operating characteristic(ROC)curves were used to evaluate the value of single factors and the multi-factor-model in predicting ARE.Results Clinical characteristics,DVH parameters and cytokine levels did not differ between the ARE and non-ARE groups.Grouped by the median of IL-12p70 before the radiotherapy,the incidence of ARE was lower in IL-12p70 high level group(P＜0.05),and there was no statistically significant difference in cytokine lev-els,DVH parametersand ARE incidence between the groups(P＞0.05).The results of Logistic regres-sion analysis showed that clinical staging,serum IL-12p70 and IL-17 levels before theradiotherapy were correlated with the occurrence of ARE(P＜0.05).The ROC curve analysis results showed that the joint model with stage,IL-12p70 was greater than median,and IL-17 greater than median had high predictive power for ARE occurrence(AUC=0.838,P＜0.000 1).Conclusion The combined model containing the 3 factors of staging,IL-12p70 and IL-17 had predictive value for the occurrence of ARE.
万方数据
维普
